Treatment with indinavir, efavirenz, and adefovir after failure of nelfinavir therapy.
نویسندگان
چکیده
A prospective, open-label study was conducted to assess the response to indinavir, efavirenz, and adefovir in human immunodeficiency virus (HIV)-infected patients experiencing viral rebound while receiving therapy with nelfinavir-containing regimens, to determine whether the protease genotype influenced the outcome of the salvage regimen. Genotyping from 29 nelfinavir failures revealed D30N in 17 (59%) and L90M in 11 (38%) cases. Suppression to <400 viral RNA copies/mL was achieved at week 48 in 56% of patients with the D30N virus versus 18% of patients with the L90M virus.
منابع مشابه
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The present population pharmacokinetic (PK) and pharmacodynamic (PD) study modeled the effects of covariates including drug adherence and the coadministration of protease inhibitors (PIs) on the pharmacokinetics of efavirenz (EFV) and the relationship between EFV exposure and virological failure in patients who failed initial PI treatment in Adult AIDS Clinical Trial Group (AACTG) study 398. We...
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Submit Manuscript | http://medcraveonline.com Abbreviations: ART: Antiretroviral Therapy; NNRTI: NonNucleoside Reverse Transcriptase Inhibitor; NRTI: Nucleoside/N Ucleotide Reverse Transcriptase Inhibitor; PI: Protease Inhibitor; AZT: Zidovudine; D4T: Stavudine; DDI: Didanosine; TDF: Tenofovir Disoproxil Fumarate; EFV: Efavirenz; NVP: Nevirapine; ETR: Etravirine; LPV/R: Lopinavir and Ritonavir;...
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عنوان ژورنال:
- The Journal of infectious diseases
دوره 187 7 شماره
صفحات -
تاریخ انتشار 2003